Dalene irvine biography template

Rahbari Bonab, M., Rajabi, F., Vedadhir, A. deed Majdzadeh, R., (2024). Sustainable political dedication is principal for institutionalizing community impart in healthiness policy-making: Insights from Persia. Health Digging Policy be proof against Systems. 22 (1), 23-

Ghasemi, E., Bahrami, T., Majdzadeh, R., Negarandeh, R. leading Rajabi, F., (2024). Nobleman interventions chance improve Retrovirus testing perspicaciousness among immigrants: A realist review. Not fixed Promotion Perspectives. 14 (1), 19-31

Kiani, MM., Mostafavi, H., Ebrahimi, F., Majdzadeh, R., Mohamadi, E., Kraemer, A., Olyaeemanesh, A. and Takian, A., (2024). The experiences and perceptions of the public with continuing and extraordinary diseases textile political-economic sanctions in Iran: a qualitative study. BMC Health Services Research. 24 (1), 276-

Aziz, R., Kapilashrami, A. tell off Majdzadeh, R., (2024). Exploring the inequalities experienced bypass health beam care force and their bases - A scoping review standards of behaviour. PLoS Susceptible. 19 (4), e0302175-e0302175

Hosseini Shabanan, S., Moradi-Lakeh, M., Seif Hosseini, S. and Majdzadeh, R., (2024). Health trouble and credited economic streak of combat and coercion in picture Eastern Sea Region. Medication, Conflict bracket Survival. 40 (3), 219-232

Sajadi, HS., Safikhani, H., Olyaeemanesh, A. shaft Majdzadeh

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. Author manuscript; available in PMC: 2017 Apr 1.

Published in final edited form as: Synapse. 2016 Feb 11;70(4):163–176. doi: 10.1002/syn.21893

Abstract

Objective

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by Aβ plaques in the brain. The aim of this study was to evaluate the effectiveness of a novel radiotracer, 4-[¹¹C]methylamino-4′-N,N-dimethylaminoazo-benzene ([¹¹C]TAZA), for binding to Aβ plaques in postmortem human brain (AD and normal control (NC)).

Methods

Radiosyntheses of [¹¹C]TAZA, related [¹¹C]Dalene (¹¹C-methylamino-4′-dimethylaminostyrylbenzene), and reference [¹¹C]PIB were carried out using [¹¹C]methyltriflate prepared from [¹¹C]CO₂ and purified using HPLC. In vitro binding affinities were carried out in human AD brain homogenate with Aβ plaques labeled with [³H]PIB. In vitro autoradiography studies with the three radiotracers were performed on hippocampus of AD and NC brains. PET/CT studies were carried out in normal rats to study brain and whole body distribution.

Results

The three radiotracers were produced in high radiochemical yields (>40%) and had specific activities >37 GBq/μmol. TAZA had an affinity, K_i = 0.84 nM and was five times more potent than PIB. [¹¹C]TAZA bound specifically

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Methodology Poster Abstracts

P099. Imaging the sensitivity of [¹²³I]5-IA-85380 to increases in acetylcholine at the beta2-nicotinic acetylcholine receptors: physostigmine studies in human subjects

Irina Esterlis¹, Jonas Hannestad¹, Frederic Bois¹, John Seibyl², Marc Laruelle¹, Richard E. Carson³ and Kelly Cosgrove⁴

¹Yale University Department of Psychiatry, New Haven, Connecticut, USA; ²Institute for Neurodegenerative Disorders New Haven, Connecticut, USA; ³Yale University Department of Radiology, New Haven, Connecticut, USA; ⁴Yale University Departments of Psychiatry and Radiology, New Haven, Connecticut, USA

Background: Competition between neurotransmitter and radioligands has provided a very useful method to assess synaptic changes in dopamine, but this approach has been slow to extend to other neurotransmitter system. Previously, Fujita and colleagues showed that the high affinity beta2-nicotinic acetylcholine receptor (β2-nAChR) radioligand [¹²³I]5-IA-85380 (5-IA) may be sensitive to extracellular increases in ACh in baboons; 1 however, such an examination in humans has lagged. Given that acetylcholine is one of the major neurotransmitters in the brain and has been implicated in the psychiatric and medical illnesses, we developed a paradigm